MARIJUANA WORKS - FEDERAL RESEARCH LEAKED - Part 1
MARIJUANA AND ITS IMPACT ON HUMAN HEALTH
CANNABIS BASED MEDICINE AND ITS IMPACT ON HUMAN HEALTH
In this feature, a physician of the highest order, Dr. David Bearman speaks about a lifetime of observations on marijuana and drug abuse. His findings overwhelmingly support the use of medical cannabis while casting doubt upon the system that has condemned its use. Implicated are shadow factions within the American shadow government.
Dr. Bearman's credentials include:
Former Director of Haight Ashbury Drug Treatment Program
Founder of Isla Vista Medical Clinic
Member of Governor Reagan's Inter-Agency Task Force on Drug Abuse
The consensus findings from over 1500 scientific and medical trials is presented. What conditions are proven to benefit from medical marijuana The medical use of marijuana dates back to more than 5300 years. The advantages of different methods to administer the various forms of medical cannabis is discussed. Government sponsored studies intending to show that cannabis has exclusively negative effects, but the findings were the exact opposite. In this feature, Dr. Bearman dispels common myths about the negative effects of cannabis and what the truth is, from exhaustive research efforts from across the world.
Dr. Bearman speaks: It’s truly amazing the number of conditions that respond favorably to marijuana. We are looking at an unexcelled wonder plant-herbal medicine that has no comparison. It would appear that marijuana and hemp were one of the first plants to be grown in agriculture. We came from being hunters and gatherers roughly ten thousand years ago ... so that’s at least the length of time a marijuana has been cultivated. Marijuana has long been known as a medicinal plant and as a product.
CANNABIS WAS THE FIRST CROP IN HISTORY
The latest findings include a tomb in China, in which the contents of the personal bag of a medicine man were discovered and one of the things it contained was marijuana. The tomb was carbon dated to almost 5000 years old. The conventional wisdom, which goes with the oral history of China is that the emperor Shennong wrote first Chinese materia-medica and that the script contained marijuana. The Emperor was alleged to have written the scribes in 2637 BC, which is almost 5000 years ago.
The oldest known copy of that manuscript goes back to about 100 BC and 100 AD. The oldest actual written record of the use of marijuana as a medicine is found in the writings in India, which describes it as an Ayurvedic medicine; that a piece of history is dated somewhere between 1100 BC and 1700 BC. Marijuana is found in every major materia-medica that has ever been written and includes the Ebers Papyrus from ancient Egypt. Cannabis was included in the writing of Dioscorides, who was Niro’s Doctor and his materia-medica was used for over a 1000 years and it was also included in the United States pharmacopeia from 1854 until 1941. So cannabis has been a medicine for a lot longer than it hasn’t been a medicine.
Evidence suggests that marijuana was used in extensively in Northern China for either shamanist purposes or for religion or healing. The culture of marijuana as medicine spread across the world. India was hugely into the use of cannabis. It was from India where W.B. O'Shaughnessy who was working for the British India Company; he picked up marijuana and imported it into the United Kingdom, where apparently it was Queen Victoria’s favored treatment for her menstrual cramps.
MAJOR DRUG COMPANIES SOLD CANNABIS IN USA AT ONE TIME
Ultimately it came to the U.S in the early part of the twentieth-century, with most of the major drug companies in this country actually producing marijuana medicine. Up until the beginning of the twentieth century marijuana was probably the second or third most commonly used medicine in the world. Marijuana was found in patent medicines that were manufactured by such familiar names is Eli Lilly, Squibb, Merck, Parke Davis, Smith Brothers. You know the Smith Brothers cough drops, cannabis was in it.
AFTER 5000 YEARS MEDICINAL USE - FDA SAYS CANNABIS HAS NO MEDICINAL USE
Medicinal cannabis was available in powdered form, whole, chopped or as a tincture. It was only in 1937 when congress enacted the cannabis tax act. That imposed a levy of a dollar an ounce for the use of medical cannabis. That was the beginning of the end for cannabis as a medicine in the United States. It was in 1942 when marijuana was totally removed from the US Pharmacopeia, or at least the formality, but up until 1942 physicians could still write prescriptions for marijuana cannabis. Since then it has not been a medicine for sixty eight years in this country, but it has been a medicine in the world for at least 3,000 years.
It was a general misconception that the use of cannabis leads to debauchery and physical violence. For that reason I guess the investigator would probably be more conservative than an they are now, but that's hard to believe, considering the way alcohol was treated in prohibition. So marijuana was prohibited, in all its uses because It had been used medicinally as well as for recreation. All uses were declared illegal and cannabis was pronounced a schedule #1 substance; which means it is a substance that is without any recognized demonstrable therapeutic effect, as opposed to cocaine, which was also declared illegal for recreational use, but still having Medicinal properties.
COCAINE AND OPIUM OK FOR MEDICAL USE
Cocaine is still used as a local anesthetic today. That's a Schedule #2 application. When the cannabis tax act was passed in 1937 immediately thereafter, Fiorello LaGuardia, who was the mayor of New York established an August body of scientists to investigate whether the claims that cannabis use was going to increase mental illness and crime in the United States were valid or not, the LaGuardia commission report was issued in 1942; they concluded that cannabis was a good medicine and that the claims that its use would increase crime and mental illness was unsubstantiated. Prohibition can and could not be enforced for the simple reason that the majority of American people do not want it enforced and are resisting its enforcement. That being so, the orderly thing to do under our form of government is to abolish, a law which cannot be in enforced, a law which the people of the country do not want enforced.
So, that sentiment was repeated in 1972 when the Nixon Marijuana Commission wrote their report. This was in the face of the admonition by president Nixon that they not recommend the legalization of marijuana for recreational use. There is a Commission that was to make recommendations to me about this marijuana legalization. The recommendation of the commission in its first report is that we do not feel that private use or private possession in one's own home should have the stigma of criminalization. People who experiment should not be criminalized for that particular behavior.
Every ten years or so our government has sponsored another look into cannabis as medicine. The last one actually now being 1999 when the Institute of Medicine did it. Every ten years, these August bodies come up with the same conclusion, that there is medicinal value to cannabis. It’s adverse effects and addictive potential gateway drugness are always way overstated and for some reason every ten years these reports go... I don't know if they are ignored, but they certainly don't seem to change policy.
In 1974, a fellow with glaucoma who was going blind named Robert Randall was arrested for possession of cannabis. He had found that using cannabis had diminished the symptoms that he was having and it was later found by both Johns Hopkins and the Jule Styne eye institute of UCLA that this was the only thing that would preserve his eyesight and the federal government then agreed to provide Mr. Randell with cannabis for medical purposes. He had made an agreement, or the government thought he had made an agreement, not to tell anybody about this.
MARIJUANA SAFER THAN EATING 1O POTATOES
Well, as soon as it happened, he told as many people as he could and people begin to apply for this program - which is called the IND (Investigational New Drug) program. At one time there were as many as 15 Americans receiving 300 hand rolled cannabis cigarettes per month from the federal government. There were another 35 people approved for the program. In 1989 the first Bush administration decided that they needed to review the program. They were concerned that too many people were applying for the program and if too many people got on it, the public might get the quote "wrong idea" that cannabis actually had some medical value - which of course it actually does have some medical value - just prior to that time.
HARMFUL TOBACCO OK - MEDICAL MARIJUANA NOT OK
In 1988 the chief administrative law judge of the food and drug administration issued a ruling recommending that cannabis be rescheduled from schedule #1 to schedule #2. In his ruling, he found that cannabis was one of the safest therapeutic agents known to man and he stated that it was safer than eating 10 potatoes. So I've always been very careful about the number of potatoes I've eaten since then. cannabis was widely used in the 19th century for the treatment of asthma and in the 1970's we found that cannabis has a Bronchodilator Effect. This is because the THC in cannabis. First of all, let's compare and contrast cannabis with the other even more widely smoke substance in our society tobacco. Tobacco was use more there than any other smoke substance and cannabis is second only to tobacco.
COMMERCIAL DIATRIBE FOR TOBACCO - AGAINST MARIJUANA
Lucy? Yes, dear. Lucy give me a cigarette, will ya honey. Don't say cigarettes, say Philip Morris. Ohhh! Is there any other kind? Not for you...Lucy you're so good to me. You see how easy it is to keep your man happy? .Why not give your husband a carton of Philip Morris cigarettes. Smart move. He will love them for their mildness, their smoothness and their wonderful good taste. He will love you too for thinking of him. That's right! Goodnight everybody.
And don't forget to call for Philip Morris. We know that if you analyse the contents of tobacco and cannabis they are quite similar and the major difference is that tobacco contains nicotine not found in cannabis and cannabis contains THC and about 60 other THC like substances called cannabinoids, not found in tobacco, but there are other a lot of other particulars are shared in common and these include carcinogens such as Benzo-A-Pyrene, the most potent of the carcinogens and considered to be responsible for a large percentage of human cancers. Benzo-A-Pyrene is found in 50 percent higher concentration in cannabis smoke than in the smoke from a comparable quantity of tobacco. This has been shown by 3 separate groups of chemical investigators so the expectation is that if you smoke cannabis enough in and on a regular basis you would encourage similar risks to smoking tobacco.
LUNG CANCER - JOINTS VS CIGARETTES
So the major health risk for tobacco emphysema, which I prefer to call the new term COPD, which consists of chronic emphysema, but there can be significant impairment of lung function without emphysema ... it could just be airways disease. Because we can't separate out the 2 components of COPD emphysema, and the airway component is lumped in together - so that COPD is the 4th leading cause of death in the U.S., It will become the world's 3rd leading cause in 2020 ... it is an especially very important disease.
STUDY - 8 YEARS OF POT SMOKING - NO HARM
About 120,000 Americans die each year from COPD, and probably the best evidence for separating, or at least the best method for separating out a patient with COPD from someone else, is to look at the rate in decline of lung function. I shouldn't say the best - it's the probably the most informative and accurate, but it's more difficult because we have to make measurements every year ... for a number of years. We have to look at the slope of rate of loss of lung function over time.
We actually measured lung function every year in cannabis smokers for up up to 8 years. We found that the slope of the decline in lung function is almost identical in the cannabis only smokers compared to non-smokers. (To be clear there is no measurable difference between cannabis smokers and non-smokers). Where it was lung function decline was accelerated was in tobacco smokers. Just one other piece of evidence - that cannabis is not a risk factor for the development of COPD.
RISK OF LUNG CANCER UP WITH TOBACCO - DOWN WITH MARIJUANA
I'm convinced of that and the other major health issue in pulmonary health consequences of tobacco is lung cancer. Cancer is the 2nd most common cause of death in the U.S.. with lung cancer being the most common form of cancer and the major risk factor of lung cancer is tobacco smoking, 160,000 Americans die each year of lung cancer, so the first question that came to mind was whether or not there was any evidence that cannabis would at least qualitatively share some of these health risks with those of tobacco. That was the rationale for initiating our studies back in the 1980's.
What is the evidence that habitual cannabis smoking cannabis can lead to lung cancer(?) We found no evidence that there is any increase risk of lung cancer occurrence in association with cannabis smoking alone. The cannabis smokers, if anything had a reduced risk for developing lung cancer. Not a significant reduced risk, but still a reduced risk - less than 1 fold (50%). So that means reduced. Whereas the tobacco smokers had markedly increased risk. Those that smoked more than 2 packs a day had a 20 fold increase in risk. That is 2000 percent.
Those that smoked from one to two packs a day had an 8 fold risk. 800 percent. So that contrasts with no risk, no increased risk, if anything a slightly reduced risk for smokers of cannabis. THC actually has an anti-tumor effect. These are studies that were done both experimentally with animals and in cell culture systems for different kinds of cancer. (THC has been shown to be fight) lung cancer, breast cancer, thyroid cancer, prostate cancer, and gliomas, which is brain cancer.... and that the development and growth of the tumor is suppressed by THC and metastases is also suppressed. So how could that be ?, well THC impairs (some kinds of) protein synthesis and it's what we call an antimitogenic anti-proliferative (agent) which means those tumor cells don't readily proliferate in the presence of THC.
"Instead of writing 5 different prescription drugs, all of which have side effects and addictive potential. I can tell my cancer patients to try cannabis to take care of any combination of those symptoms."
So it interferes with the growth and development of new blood vessels are necessary for it to spread of cancer. They also are Proapoptotic. What is a Proapoptotic? It is programmed cell death so when cells age, there is a mechanism whereby the cells die. It is a non-necrotic death and the die off of old cells and we get rid of them before they have an opportunity to develop mutations that would lead to cancer. So enhancing a Proapoptotic effect diminishes the risk of the cells become cancerous. Cannabis or THC turns out to be Proapoptotic. Those appear to be the mechanisms that might account for these antitumoral effects of THC. We decided to do our own case control study.
THE LARGEST STUDY ON THC AND MARIJUANA
Funding came from from the National Institute on Drug Abuse, which is a major agency for cannabis related research. This is the largest study ever conducted on this subject. It was very well designed. We used the Los Angeles tumor registry to identify and rapidly ascertain all the cases of lung cancer, head, neck cancer... cancers that were diagnosed in the LA county system ... and of course by the time we got to some of them, they had already died or were too sick, but we got to it nonetheless. Over sixty percent of them who agreed to participate and we administered a questionnaire. Then we matched them to controls of the same age, socioeconomic status, within the same neighborhood using an algorithm which USC developed for this (exclusively). So, then we could match comparing apples with apples.
Next we administered this detailed questionnaire. Also, in molecular (testing) we got buckle of smears so we could look at DNA.... to look at genetics in lung cancer. So, what we did was to recruit marijuana smokers. Heavy smokers of cannabis at least a joint a day for a week and it ended up that the average smoker of cannabis who we recruited smoked about 3 joints a day for about 15 years. We also required that they smoked that much for five years, but the average they smoked was 15 joints for fifteen years so that's = about 45 to 50 Joint years. A Joint year, is the average number of joints smoked, times the number of years smoked. Over the study population was, I think between 35 and 59.... Of course, we thought that they have to be teenagers in the early twenties at the time of the cannabis epidemic, which you know was in the in the mid 1960's.
Prior to that time, very few people used cannabis, after that time it just mushroomed up to 1979. Represented the apex, that means the active use in society, that is why we chose those age limits and so would be find data for any category of marijuana use, including heavy use (defined as more than 10 joint years) we look at 10, 20,30 years.
For every category of cannabis use, the ratio was less than 1, which means reduced risk. It was not significantly reduced, but it was reduced. The compensate tables were not that wide, so there was no evidence, we control for all accumulated factors of such economic status in common. At the same time, we did a similar analysis on tobacco smokers and there was a huge effect from tobacco.....
I am a cancer doctor and everyday I see patients with cancer who have nausea from their chemotherapy or their cancer; loss of appetite, pain, depression, insomnia. My experience over the past thirty years of being an oncologist is that there's one medicine (cannabis) that I could recommend to patients that can take care of all those problems.
Instead of writing 5 different prescription drugs, all of which have side effects and addictive potential. I can tell my cancer patients to try cannabis to take care of any combination of those symptoms. The first study that I really wanted to do was in patients with the so-called AIDS wasting syndrome, which was something we saw before the availability of antiretroviral drugs.... and patients with HIV infections just wasted away. They lost weight, they got diarrhea and fevers.
Dronabinol or synthetic delta 9 THC became available to help those patients increase their appetite. When we prescribe those patients dronabinol in the early 1990's they said "you know this is okay, but I really prefer to smoke real marijuana because when you take marijuana by mouth either as delta 9 THC or eating in fact baked products the absorption is very slow and variable so it takes about two and a half hours for peak to be reached and the peak level in the blood is quite low and it stays in the body for quite a long time as well.
Also, when taken by mouth the delta 9 THC becomes converted by liver to another psychoactive metabolite, so people that take dronabinol or take marijuana baked products often get more zonked (tired) than people who smoke because when you smoke, you don't get that second metabolite, and so when you smoke you get a very rapid peak in the blood of in two and a half minutes, as opposed to two and a half hours. People can really control the onset of the activity and people can really control the onset of the activity, and how long it lasts better if they're smoking, rather than taking a pill or eating a baked product.
STUDY - COMPARE DRONABINOL WITH REAL MARIJUANA
So, our first study that we hoped to do in the early 1990's was to show that smoked marijuana was better than dronabinol in increasing appetite in patients with AIDS wasting syndrome. I tried twice to get marijuana from the government because they're the only legal source of cannabis for clinical trials. Both times I failed and then went to Alan Leshner, who at the time was the head of the national institute on drug abuse. He explained to me, in fact, that the government NIDA, The National Institute on Drug abuse has a congressional mandate only to study substances of abuse as substances of abuse. So my requests have cannabis to study it has the potential therapeutic agent could never be granted by the government, because again congress says you can only study these substances as substances of abuse and not as treatments for disease.
See Part 2 for the conclusion of the research findings of Dr. Bearman
MMJDoctoronline Notes: As a result of the brave work by Dr. Bearman and others, med and rec marijuana is now legal in California, Nevada and many other states. Until 2018, a medical evaluation from a medical doctor is required to purchase cannabis based medicines from compassion clubs, clinics, cooperatives, dispensaries, and delivery services. We provide Cannabis Identification, licensed physician's recommendations and growers permits, valid in Nevada and California. The MMJ process is completed entirely online and takes a couple of minutes only. Approval takes a few hours and patients recommendation and ID is mailed same day in a non marijuana marked envelope.