MARIJUANA WORKS - FEDERAL RESEARCH LEAKED - Part 2
CANNABIS BASED MEDICINE AND ITS IMPACT ON HUMAN HEALTH
....Continued from MARIJUANA AND ITS IMPACT ON HUMAN HEALTH
NEGATIVE RESEARCH FUNDABLE ONLY
In 1996, the terrain changed when we got HIV drugs that actually work and we didn't see the wasting syndrome anymore, but these drugs were broken down by liver by the same pathway that metabolites some illegal substances. Then there was a report in the literature of the patient dying from ecstasy overdose. It was one of the AIDS antiviral drugs that they took with ecstasy at the same time. So I said, haha, a little light bulb went off. Maybe I should study to see if it's safe for patients on the AIDS antiretroviral drugs to smoke marijuana. So I submitted that grant to the government and that work within their schema, because I was looking to see if it was harmful.
With that application I finally succeeded .... and got a million dollars and 1,400 government (cannabis) cigarettes to study in patients with HIV. Now these patients didn't have the wasting syndrome anymore, but the endpoint of our study was to see if there a change in the amount of the aids virus in the blood stream after 21 days of exposure to either - 3 government cigarettes a day or - three dronabinol capsules or - 3 placebo capsules. We looked at the change in the HIV virus and it didn't change at all. We also look at the interaction between cannabinoids either smoke or oral and the amount of AIDS drug in bloodstream that didn't change clinically significantly either.
CANNABIS AND THE IMMUNE SYSTEM
We also knew that people were concerned that cannabis might have an impact on the immune system that could be negative and we took a look at that very carefully. In these HIV patients we found no evidence of any negative affect and perhaps some have a benefit in the immune system in patients smoking even more than taking the capsules. In my opinion, the whole plant is medicine that nature provided and it is the best medicine. It is truly amazing the number of conditions that respond favorably to marijuana.
The #1 condition is pain. marijuana is useful again relieving people's pain and is particularly effective in relieving pain from connective tissue disorders. Arthritis, fibromyalgia, systemic lupus, reflex sympathetic dystrophy. A whole host of conditions that we don't really understand very well, people seem to get good relief from marijuana. People are able to decrease the amount of opiates that they're taking and in some instances, to stop taking opiates entirely for pain control. The first modern research that was done marijuana was done in 1949 demonstrate its usefulness in treating epilepsy. I have a number of people who don't have epilepsy when they use marijuana regularly.
The founder of modern medicine is a Physician named Sir William Osler. He was prominent around the turn of the nineteenth or twentieth century, and wrote the first textbook of internal medicine. In that textbook he said the marijuana was the most effective medication for the treatment of migraine headaches and I certainly have a number of people with migraines that get substantial relief or even prevention of migraines by consumption of marijuana.
CANNABIS SPECIALTY - DISEASES OF THE TUMMY
Other conditions that commonly respond favorably to cannabis include depression, helps people with sleep, helps with appetite. It is also very good training GI symptoms, nausea, diarrhea, it is excellent for treating Crohn's disease. We did a little study of people with Crohn's disease and found that many of them were able to stop using steroids, to stop using other medications that they had been taking for their Cronies that they have less diarrhea and less abdominal pain. It was a true miracle for them.
There is a list here of conditions that was originally developed by doctor Tod Mikuriya, a pioneer in terms of medical cannabis. He actually worked for the National Institute of Mental Health and his job was to give out grants for doing studies on marijuana. He thought he was there to find out how marijuana was useful in treating medical conditions.
"NIMH thought he was there to hand out grants to see how dangerous it was."
This was a marriage made hell and needless to say he did not stay with NIMH for very long. Marijuana is seen as a protecting agent and we have found that it has provided benefits for people with multiple sclerosis. It treats the pain in their muscle spasm, but more importantly, people who were placed on Sativex, the tincture of marijuana in early studies in Great Britain have remained on it for years and years and rather than progress, the multiple sclerosis has stayed the same.
THE MANY DISEASES TREATED WITH CANNABIS
Suggesting that marijuana may not only be effective in reducing the symptoms, but also in slowing the progression of disease. it is helpful when dealing with anxiety in people that have Alzheimer's disease. Cannabis is helpful in dealing with the muscle spasms that associated with Parkinson's disease. When it comes to psychological illnesses marijuana is useful not only treating depression, which are already mentioned, but also bipolar disorder, which is depression plus mania. It is useful in treating (ADD) attention deficit disorder, post-traumatic stress disorder as demonstrated in a study done at the Max Planck Institute in Germany.
"Both the Israeli government and the Croatian government have given their troops marijuana for treatment of PTSD."
A few years back, cannabis was demonstrated to be useful in reducing fearful memory, so that might suggest it could be used for alleviating PTSD. This is extremely important to mention at this time, when we have so many people who are serving multiple tours in Iraq and Afghanistan. The pentagon has projected that at least a third of these people - and I think that is a very conservative estimate - will come back up with the symptoms of PTSD. Matter of fact, in regards to PTSD of both the Israeli government and the Croatian government have given their troops marijuana for treatment of PTSD.
The list just goes on and on. Many, many serious painful conditions like spondylitis, which can actually turn you over or make you bend over in a crippled position - people who have failed back surgery - people who have herniated disks, - those who have chronic dislocated shoulders. All of these people get relief from marijuana and they find that the it provides that relief, with fewer side effects than the opiates do.
"There were numerous cannabis cigarettes on the market in the 1920's for the treatment of asthma."
Another thing that is sort of counter intuitive is in the treatment of asthma. You may have seen the ads for Advair; both the bronchodilator and anti-inflammatory. Well, so too is marijuana. This is why there were numerous cannabis cigarettes on the market in the 1920's for the treatment of asthma specifically for at the treatment of asthma. So, as I pointed out by holding up a list of conditions for which marijuana is useful, is extremely lengthy. That's a quick overview of some of the conditions that marijuana is useful in treating. Most people tend to take marijuana at least in the evening, some people take it more often than that and the reason is that many of these conditions interfere with sleep. Then there are some people who just have sleep problems, have insomnia difficulty. Marijuana is very useful assisting people and going to sleep.
ADMINISTRATION METHODS OF CANNABIS
Now if they have difficulty staying asleep, in addition to smoking or vaporizing or using it sublingually, they should also use it as an edible or drink, it's because it will kick in 45 minutes into their sleep, and it will be effective for about 5 to 6 hours. There are a number of ways of administering marijuana. Smoking and vaporizing cause the chemicals to get into the body, upstream of the liver. So you have unmetabolized cannabinoids that are going to the brain. Now this doesn't mean that when the cannabinoids go to the liver that they are inactivated, but it means that they're different... 85 percent of the cannabinoid is metabolize on its first pass to liver.
The other thing is that when cannabinoids go to the brain immediately by the respiratory route of administration, the effect will be in 15-30 seconds. Whereas, if we wait for it to go through the GI Tract to deliver, it will take 45 minutes before it's effective. Now each one of those routes of administration is going to give you a slightly different mix of chemicals because, when you smoke it, you are oxygenating the chemicals that are in there. So when you are vaporizing the cannabinoids that are behind where the flame is you're also burning them right at the junction .... so that smoked cannabis is not identical to vaporizing cannabis.
With the vaporized cannabis, all the volatilized oils will be vaporized by the time you get to 340 degrees C,. you will have removed or been exposed to about 70 percent fewer irritants then when you smoke it. It also has a somewhat different odor, it doesn't have the characteristic classic burn rope odor, it has more of a nutty odor. Now when you eat cannabis you're going to have metabolized 85 percent of cannabinoids. People who eat it, talk about having a body high as opposed to mind high.
That is because you are being exposed to a different combination of cannabinoids. Now, some people have found that an under the tongue spray, which is what Sativex is, Sativex is an alcohol extract of the whole plant, which combines extracts from two plants.... one that is high in THC for its therapeutic value and another that is high in CBD .... to keep down excessive euphoria. When you spray it under the tongue it will be effective in about 15 minutes, but it will go to the brain first before going through the liver.
On the other hand, there are many people in Canada, where Sativex is legal that find that they still prefer marijuana to Sativex. Now Sativex is prescribed in Canada and it appears as though the British government and or the Spanish government, it might also approve Sativex in the near future for sale as a pharmaceutical in their country. The US Food Drug Administration (FDA) found that Sativex, basically liquid cannabis was safe enough to be tested on Americans and they approved a Phase 3 clinical study in December of 2005, to determine whether or not this under the tongue tincture spray was useful in intractable pain of people with cancer. Phase 3 just means a study on human beings, This study did not get started until 2007 and still ongoing.
SIDE EFFECTS OF CANNABIS
There have been numerous other studies with marijuana and tinctures of marijuana for hurt that have shown to be useful in relieving pain. We talked about under the tongue, we've talked about smoking, talked about being vaporization....there's also these synthetic delta 9 THC that can be taken orally just like edibles. The main problem with edibles is that it's hard to tell whether you're going to get a dose that is going to just deal with the therapeutic needs that you have, whether it's going to give you euphoria, or whether it is going to give you dysphoria. You need to have the regular supply so that you can be fairly certain that you're going to take the amount that will be the therapeutic dose and not an amount that will give you dysphoric side-effects.
Lastly, the .... who are healers in Southern Mexico and Central America have used tincture of marijuana as part of their therapeutic for at least 200 years. The topical application of tincture of marijuana is useful, particularly on the small joints the fingers and toes in dealing with pain associated with arthritis and the reason for this is that marijuana is both an Analgesic, a painkiller and anti-inflammatory and we know this not only from the evidence that we have, but also from thousands of studies that have been done around the world, mainly with animals and sometimes tissue culture.
The International Cannabinoid Research Society's been around for about 20 years and they have conferences each year that last three days, in which researchers from all over the world talk about the results they have gotten from doing basic science studies. Any drug that a doctor's considering recommending or prescribing, they need to balance off the therapeutic effects with the side-effects. When you talk about the treatment of pain for many people, the opiates are very effective pain killers, but for some people the opiates cause confusion.
SIDE EFFECTS EXIST - SOME EXAGGERATED
They make it difficult for them to concentrate and it is difficult for them to drive. They don't enjoy playing with their kids and their grandkids, it causes them constipation. With marijuana for many of those people, they find that it certainly does not give them constipation and does not cause them confusion, but provides them with sufficient relief from their pain ... so they can go about their activities of daily living. They can drive their car without interference and more importantly, they can have fun, they can play with their children, they can play with their grandchildren... so I wouldn't necessarily say that across the board, marijuana is to be used instead of opiates.
But I would say that for many people, it can be used to instead of opiates and for others it can be used in conjunction with opiates and they can use a lower dose of the opiates with hopefully fewer side effects. Now, any therapeutic agent that we know of has some side effects and cannabis is no exception. The main side-effect to the use of cannabis is from smoking it and that is cough. So that can be completely avoided by eating it or drinking. or largely avoided by vaporizing it.
One of the things that is talked about a lot is that - you can have a panic reaction and that is certainly possible; it most commonly occurs in people who are no-vices users and particularly, if they've been exposed to plant that is very high in THC. Another thing that people sometimes have is paranoid thinking - that the police are after them. I've noticed that this is not nearly used common since it has become legal because the police are not after them and so it may not be paranoia that people were experiencing - but an exaggerated perception of reality - and one of the things we have lost as a result of the propaganda misinformation that is spread about marijuana and the fact that it has legitimate therapeutic value and we have discouraged research.
USA DISCOURAGES RESEARCH - ISRAEL AND CANADA ENCOURAGE
We have dramatic discouraged research in this country and numerous other countries, including England, Israel, Spain and Germany are far ahead of us, in terms of quantity of research ... that they are doing on the medicinal value of marijuana. This is particularly alarming in these economic times, when we certainly could use the economic stimulus and the economic boost that would come from having pharmaceutical marijuana available in the country, as it is now in Canada and possibly soon will be in England and Spain.
Thomas Jefferson said that this country would be in dire straits if we have laws that interfered with what we put into our own bodies. Are we not in control of our own bodies? Cannabis is a medicine that patients themselves can grow. For people with cancer who may be facing thinking about the end of their life to be able to grow a plant in work in the garden and produce their own medicine is very empowering and it's something that I think does a patient a lot of good. Cannabis is illegal and the government does not sponsor this kind of research. In view of the fact that large numbers of people are using cannabis medicinally I think it's a shame that there is no investment in this kind of research.
DRUGS SHOULD BE USED ONLY WHEN NECESSARY
I think that there is a very bright future for medical marijuana in this country. I grew up around drugs, but to me drugs are a good thing. I walked into building everyday almost of my first 18 years that had a 13 foot tall sign that said Drugs... my father was a pharmacist and we sold medication. As far as I am concerned medication is helpful to people I don't think that medication has personality and sits on the shelf until you prescribe it for somebody. It has beneficial use and has side effects and should only be used when necessary.
MMJDoctoronline Notes: As a result of pioneering work by Dr. David Bearman and others, medical and recreational marijuana is now legal in California, Nevada and many other states. Until 2018, a medical recommendation from a medical doctor is required to purchase cannabis based medicines from dispensaries, compassion clubs, clinics, cooperatives and delivery services. We provide Cannabis ID, licensed doctor's recommendations and grow permits, valid in California and Nevada. This process is completed 100% online and takes only a few minutes to complete. Approval is same day and r recommendation is emailed with your your ID following in the mail.